- Kev siv cov ntaub ntawv kho mob
- Kev siv cov ntaub so ntswg engineering
- Kev siv hlawv
- Daim ntawv thov kev zoo nkauj
Collagen yog ib hom dawb, opaque, branchless fibrous protein, uas feem ntau muaj nyob rau hauv daim tawv nqaij, pob txha, pob txha mos, hniav, tendons, ligaments thiab cov hlab ntsha ntawm cov tsiaj.Nws yog ib qho tseem ceeb heev cov txheej txheem protein ntawm cov ntaub so ntswg sib txuas, thiab ua lub luag haujlwm hauv kev txhawb nqa lub cev thiab tiv thaiv lub cev.Nyob rau hauv xyoo tas los no, nrog kev txhim kho ntawm collagen extraction technology thiab kev tshawb fawb tob ntawm nws cov qauv thiab cov khoom, cov kev ua haujlwm lom neeg ntawm collagen hydrolysates thiab polypeptides tau maj mam lees paub.Kev tshawb fawb thiab kev siv ntawm collagen tau dhau los ua kev tshawb fawb hotspot hauv tshuaj, zaub mov, tshuaj pleev ib ce thiab lwm yam lag luam.
Collagen yog ib qho protein ntau ntawm lub cev.Nws muaj affinity zoo rau cov protein molecules ntawm daim tawv nqaij nto, tsis muaj zog antigenicity, zoo biocompatibility thiab biodegradation kev nyab xeeb.Nws tuaj yeem degraded thiab absorbed, thiab muaj adhesion zoo.Kev phais suture ua los ntawm collagen tsis tsuas yog muaj lub zog zoo tib yam li tej yam ntuj tso txhob lo lo ntxhuav, tab sis kuj muaj lub absorbability.Thaum siv, nws muaj cov platelet aggregation zoo heev, zoo hemostatic nyhuv, zoo smoothness thiab elasticity.Lub suture hlws ris tsis xoob, lub cev nqaij daim tawv tsis puas thaum lub sij hawm ua hauj lwm, thiab nws muaj zoo adhesion rau lub qhov txhab.Nyob rau hauv ib txwm muaj xwm txheej, tsuas yog lub sij hawm luv luv ntawm compression tuaj yeem ua tiav cov txiaj ntsig zoo hemostatic.Yog li collagen tuaj yeem ua hmoov, tiaj tus thiab spongy hemostatic.Nyob rau tib lub sijhawm, kev siv cov khoom siv hluavtaws lossis collagen hauv cov khoom siv plasma, cov tawv nqaij, cov hlab ntsha, cov pob txha kho thiab cov pob txha pob txha thiab cov enzyme immobilized yog cov kev tshawb fawb thiab kev siv ntau heev.
Collagen muaj ntau pawg reactive ntawm nws cov molecular peptide saw, xws li hydroxyl, carboxyl thiab amino pawg, uas yooj yim rau nqus thiab khi ntau yam enzymes thiab hlwb kom ua tiav immobilization.Nws muaj cov yam ntxwv ntawm kev sib raug zoo nrog cov enzymes thiab hlwb thiab muaj zog yoog raws.Tsis tas li ntawd, collagen yog ib qho yooj yim rau txheej txheem thiab tsim, yog li purified collagen tuaj yeem ua rau ntau hom ntaub ntawv, xws li daim nyias nyias, daim kab xev, daim ntawv, daim txhuam cev, hlaws, thiab lwm yam, tab sis daim ntawv thov ntawm daim ntawv membrane feem ntau tshaj tawm.Ntxiv nrog rau biodegradability, cov ntaub so ntswg absorbability, biocompatibility thiab tsis muaj zog antigenicity, collagen daim nyias nyias yog siv nyob rau hauv biomedicine.Nws kuj muaj cov yam ntxwv nram qab no: muaj zog hydrophilicity, siab tensile zog, derma zoo li morphology thiab qauv, thiab zoo permeability rau dej thiab huab cua.Bioplasticity txiav txim siab los ntawm lub zog tensile siab thiab qis ductility;Nrog ntau pab pawg ua haujlwm, nws tuaj yeem raug sib txuas kom tsim nyog los tswj nws tus nqi biodegradation.Adjustable solubility (soo);Nws muaj cov nyhuv synergistic thaum siv nrog lwm cov khoom siv bioactive.Muaj peev xwm cuam tshuam nrog tshuaj;Kev sib txuas los yog kev kho enzymatic ntawm kev txiav txim siab peptides tuaj yeem txo cov antigenicity, tuaj yeem cais cov kab mob, muaj kev ua haujlwm ntawm lub cev, xws li ntshav coagulation thiab lwm yam zoo.
Cov ntawv thov kev kho mob yog cov tshuaj aqueous, gel, granule, daim txhuam cev thiab zaj duab xis.Ib yam li ntawd, cov duab no tuaj yeem siv rau kev tso tshuaj qeeb.Kev tso tawm qeeb ntawm cov tshuaj collagen uas tau pom zoo rau kev ua lag luam thiab tab tom txhim kho feem ntau yog tsom rau kev tiv thaiv kab mob thiab kev kho mob glaucoma hauv ophthalmology, kev kho mob hauv zos hauv kev raug mob thiab kev tiv thaiv kab mob hauv kev kho qhov txhab, ncauj tsev menyuam dysplasia hauv gynecology thiab tshuaj loog hauv zos hauv kev phais. , lwm.
Kev faib tawm thoob plaws hauv tag nrho cov ntaub so ntswg ntawm tib neeg lub cev, collagen yog ib qho tseem ceeb ntawm tag nrho cov ntaub so ntswg thiab tsim cov extracellular matrix (ECM), uas yog cov ntaub so ntswg scaffold khoom.Los ntawm kev xav ntawm kev kho mob daim ntawv thov, collagen tau siv los ua ntau yam ntaub so ntswg engineering scaffolds, xws li daim tawv nqaij, pob txha cov ntaub so ntswg, trachea thiab hlab ntsha scaffolds.Txawm li cas los xij, collagen nws tus kheej tuaj yeem muab faib ua ob pawg, xws li scaffolds ua los ntawm cov ntshiab collagen thiab cov Scaffolds ua los ntawm lwm cov khoom.Ntshiab collagen cov ntaub so ntswg engineering scaffolds muaj qhov zoo ntawm biocompatibility zoo, ua haujlwm yooj yim, plasticity, thiab tuaj yeem txhawb nqa cell adhesion thiab proliferation, tab sis kuj tseem muaj qhov tsis zoo xws li cov khoom siv tsis zoo ntawm collagen, nyuaj rau cov duab hauv dej, thiab tsis tuaj yeem txhawb nqa cov ntaub so ntswg. .Qhov thib ob, cov ntaub so ntswg tshiab ntawm qhov chaw kho yuav tsim ntau yam enzymes, uas yuav hydrolyze collagen thiab ua rau lub disintegration ntawm scaffolds, uas tuaj yeem txhim kho los ntawm kev sib txuas los yog kev sib txuas.Biomaterials raws li collagen tau ntse siv hauv cov ntaub so ntswg engineering cov khoom xws li cov tawv nqaij, pob txha pob txha, pob txha mos grafts thiab paj catheters.Cov pob txha pob txha raug kho tau siv collagen gels kos rau hauv chondrocytes thiab tau sim ua kom xa cov epithelial, endothelial, thiab pob txha hlwb rau collagen sponges kom haum cov ntaub so ntswg pob txha.Lwm tus muab cov qia hlwb los ntawm autogenous mesenchymal hlwb nrog collagen gel ua cov leeg rau kev kho tom qab.
Cov ntaub so ntswg-engineered khoom siv tawv nqaij cov tshuaj txhawb nqa-tso cov nplaum tsim los ntawm dermis thiab epithelium nrog collagen raws li matrix yog siv dav hauv kev xa tshuaj nrog collagen ua cov khoom tseem ceeb, uas tuaj yeem tsim cov tshuaj collagen aqueous rau ntau hom tshuaj xa khoom.Piv txwv xws li collagen protectors rau ophthalmology, collagen sponges rau kub hnyiab los yog raug mob, hais rau protein xa, gel cov ntaub ntawv ntawm collagen, tswj cov ntaub ntawv rau cov tshuaj xa los ntawm daim tawv nqaij, thiab nanoparticles rau gene kis.Tsis tas li ntawd, nws tseem tuaj yeem siv los ua substrate rau cov ntaub so ntswg engineering nrog rau cov kab lis kev cai ntawm tes, cov khoom siv scaffold rau cov hlab ntsha thiab li qub, thiab lwm yam.
Autologous daim tawv nqaij grafts yog lub ntiaj teb no tus qauv rau kev kho mob thib ob - thiab thib peb-degree kub.Txawm li cas los xij, rau cov neeg mob uas kub hnyiab heev, qhov tsis haum ntawm daim tawv nqaij grafts tau dhau los ua qhov teeb meem loj tshaj plaws.Qee tus neeg tau siv cov txheej txheem bioengineering los loj hlob cov ntaub so ntswg ntawm cov menyuam mos ntawm daim tawv nqaij.Kev kub hnyiab zoo nyob rau hauv ntau qhov sib txawv hauv 3 lub lis piam mus rau 18 lub hlis, thiab cov tawv nqaij tshiab tshiab qhia me ntsis hypertrophy thiab tsis kam.Lwm tus siv hluavtaws poly-DL-lactate-glycolic acid (PLGA) thiab ntuj collagen kom loj hlob peb-dimensional tib neeg daim tawv nqaij fibroblasts, qhia tias: Cells loj hlob sai ntawm hluavtaws mesh thiab loj hlob yuav luag ib txhij nyob rau hauv thiab sab nraud, thiab proliferating hlwb thiab secreted. extracellular matrix tau zoo ib yam.Thaum cov fibers tau muab tso rau hauv lub nraub qaum ntawm tus nas dermal, cov ntaub so ntswg dermal loj hlob tom qab 2 lub lis piam, thiab cov ntaub so ntswg epithelial loj hlob tom qab 4 lub lis piam.
Collagen yog muab rho tawm los ntawm cov tsiaj tawv nqaij, daim tawv nqaij ntxiv rau collagen kuj muaj hyaluronic acid, chondroitin sulfate thiab lwm yam proteoglycan, lawv muaj ib tug loj tus naj npawb ntawm polar pawg, yog ib tug moisturizing yam, thiab muaj cov nyhuv ntawm kev tiv thaiv tyrosine nyob rau hauv daim tawv nqaij kom hloov mus rau hauv lub cev. melanin, yog li collagen muaj ntuj moisturizing, whitening, anti-wrinkle, freckle thiab lwm yam dej num, tuaj yeem siv dav hauv cov khoom zoo nkauj.Collagen cov tshuaj muaj pes tsawg leeg thiab cov qauv ua rau nws lub hauv paus ntawm kev zoo nkauj.Collagen muaj cov qauv zoo sib xws rau tib neeg daim tawv nqaij collagen.Nws yog cov protein uas tsis yog dej-soluble fibers uas muaj suab thaj.Nws cov molecules yog nplua nuj nyob rau hauv ib tug loj tus naj npawb ntawm cov amino acids thiab hydrophilic pawg, thiab nws muaj tej yam kev ua si nto thiab zoo compatibility.Ntawm 70% txheeb ze av noo, nws tuaj yeem khaws 45% ntawm nws tus kheej qhov hnyav.Cov kev ntsuam xyuas tau pom tias cov tshuaj ntshiab ntawm 0.01% collagen tuaj yeem tsim cov txheej txheem dej zoo, muab tag nrho cov dej noo ntawm daim tawv nqaij.
Nrog rau kev loj hlob ntawm lub hnub nyoog, lub peev xwm hluavtaws ntawm fibroblast txo.Yog tias daim tawv nqaij tsis muaj collagen, collagen fibers yuav co-solidified, uas ua rau txo qis ntawm intercellular mucoglycans.Cov tawv nqaij yuav poob nws softness, elasticity thiab luster, uas ua rau aging.Thaum nws yog siv los ua ib qho khoom siv hauv cov tshuaj pleev ib ce, tom kawg tuaj yeem kis mus rau txheej tob ntawm daim tawv nqaij.Lub tyrosine nws muaj kev sib tw nrog tyrosine nyob rau hauv daim tawv nqaij thiab khi rau lub catalytic chaw ntawm tyrosinase, yog li inhibiting zus tau tej cov melanin, pab txhawb kev ua si ntawm collagen nyob rau hauv daim tawv nqaij, tswj cov dej noo ntawm stratum corneum thiab kev ncaj ncees ntawm cov fiber ntau. , thiab txhawb cov metabolism hauv daim tawv nqaij.Nws muaj zoo moisturizing thiab moisturizing nyhuv ntawm daim tawv nqaij.Thaum xyoo 1970s, bovine collagen rau kev txhaj tshuaj yog thawj zaug hauv Tebchaws Meskas kom tshem tawm cov pob thiab wrinkles thiab kho cov nti.
Post lub sij hawm: Jan-04-2023