High-purity shark chondroitin sulfate yog cov khoom tseem ceeb rau kev kho mob sib koom ua ke
Chondroitin sulfate (CS) yog ib qho tseem ceeb glycosaminoglycan uas yog covalently txuas rau cov proteins los tsim proteoglycans.Nws yog dav faib nyob rau hauv lub extracellular matrix thiab cell nto ntawm cov ntaub so ntswg tsiaj, thiab yog ib qho tseem ceeb ntawm cov tsiaj connective cov ntaub so ntswg, uas yog tshwj xeeb tshaj yog muaj nyob rau hauv pob txha mos.Lub hauv paus qauv ntawm chondroitin sulfate yog tsim los ntawm alternating ligation ntawm D-glucuronic acid thiab N-acetylgalactosamine los ntawm glycosidic bonds, uas txuas ntxiv mus rau lub hauv paus ntawm cov protein los tsim ib tug complex proteoglycan qauv.
Shark-derived chondroitin sulfate yog ib tug ntawm lawv, uas yog ib tug acidic mucopolysaccharide tshuaj npaj los ntawm shark pob txha mos cov ntaub so ntswg.Nws zoo nkaus li cov hmoov dawb lossis dawb zoo li hmoov, tsis muaj ntxhiab tsw, nruab nrab saj.Chondroitin shark sulfate yog ib qho ntawm cov khoom tseem ceeb ntawm cov ntaub so ntswg mammalian connective, thiab nws yog dav pom nyob rau hauv pob txha mos, pob txha, tendons, ligaments, sarcolemma, thiab cov hlab ntsha phab ntsa.
Nws ua raws li kev tuav cia thiab kev txhawb nqa hauv pob txha pob txha.Kev noj nruab nrab ntawm chondroitin sulfate tuaj yeem pab tswj cov pob txha mos, txo qhov o thiab mob, txhim kho kev sib koom tes, thiab muaj kev nyab xeeb siab.Nws feem ntau yog siv ua ke nrog glucosamine, kev sib xyaw ua ke uas kho tau zoo txhim kho qhov mob nruab nrab mus rau qhov mob hnyav hauv osteoarthritis thiab txhawb nqa cov collagen tshiab thiab proteoglycans hauv chondrocytes.
| Khoom npe | Shark Chondroitin Sulfate Soidum |
| Keeb kwm | Shark Keeb Kwm |
| Txuj kev zoo | USP40 Txuj |
| Qhov tshwm sim | Dawb rau tawm dawb hmoov |
| CAS Nr | 9 082-07-9 |
| Cov txheej txheem ntau lawm | Cov txheej txheem enzymatic hydrolysis |
| Cov ntsiab lus protein | ≥ 90% los ntawm CPC |
| Poob rau ziab | ≤ 10% |
| Cov ntsiab lus protein | ≤ 6.0% |
| Muaj nuj nqi | Kev Pab Txhawb Kev Noj Qab Haus Huv, Pob Txha thiab Pob Txha |
| Daim ntawv thov | Khoom noj khoom haus hauv ntsiav tshuaj, Capsules, lossis hmoov |
| Halal Certificate | Yog, Halal Verified |
| GMP Status | NSF-GMP |
| Daim ntawv pov thawj kev noj qab haus huv | Yog, daim ntawv pov thawj kev noj qab haus huv muaj rau kev cai tshem tawm lub hom phiaj |
| Txee lub neej | 24 lub hlis txij li hnub tsim khoom |
| Ntim | 25KG / Nruas, Pem Hauv Ntej: Muab ob npaug rau PE Hnab, Ntim Cov Khoom: Ntawv Nruas |
| Yam khoom | SPECIFICATION | KEV TIV THAIV |
| Qhov tshwm sim | Off-dawb crystalline hmoov | Pom kev |
| Kev txheeb xyuas | Cov qauv paub meej nrog lub tsev qiv ntawv siv | Los ntawm NIR Spectrometer |
| Lub infrared absorption spectrum ntawm tus qauv yuav tsum pom maxima nkaus xwb nyob rau tib lub wavelengths li ntawm chondroitin sulfate sodium WS. | Los ntawm FTIR Spectrometer | |
| Disaccharides muaj pes tsawg leeg: Qhov piv ntawm cov lus teb siab tshaj plaws rau △DI-4S rau △DI-6S tsis tsawg dua 1.0 | Enzymatic HPLC | |
| Optical Rotation: Ua tau raws li qhov yuav tsum tau ua rau kev sib hloov kho qhov muag, kev sib hloov tshwj xeeb hauv cov kev sim tshwj xeeb | USP 781 S | |
| Assay (Odb) | 90% -105% | HPLC |
| Poob Thaum Qhuav | <12% | USP731 |
| Protein | <6% | USP |
| Ph (1% H2o Solution) | 4.0-7.0 Nws | USP791 |
| Kev sib hloov tshwj xeeb | -20° ~ -30° | USP 781 S |
| Residue On Ingition (Dry Base) | 20% -30% | USP 281 |
| Organic Volatile Residual | NMT 0.5% | USP467 |
| Sulfate | ≤ 0.24% | USP 221 |
| Chloride | ≤ 0.5% | USP 221 |
| Clarity (5% H2o daws) | <0.35@420nm | USP38 |
| Electrophoretic Purity | NMT 2.0% | USP 726 |
| Txwv tsis pub muaj cov disaccharides tshwj xeeb | 10% | Enzymatic HPLC |
| Hnyav Hlau | ≤ 10 ppm | ICP-MS |
| Tag nrho cov phaj suav | ≤1000cfu / g | USP 2021 |
| Poov & Pwm | ≤100cfu / g | USP 2021 |
| Salmonella | Tsis muaj | USP 2022 |
| E. Coli | Tsis muaj | USP 2022 |
| Staphylococcus Aureus | Tsis muaj | USP 2022 |
| Particle Loj | Customized raws li koj xav tau | Hauv Tsev |
| Kev ceev ceev | > 0.55g / ml | Hauv Tsev |
Ua ntej, chondroitin sulfate yog ib qho glycosaminoglycan uas tau pom dav dav ntawm cov ntaub so ntswg extracellular.Nyob rau hauv cov pob txha, nws yog tsuas yog pom nyob rau hauv periphery ntawm chondrocytes thiab yog ib qho tseem ceeb ntawm cov pob txha mos extracellular matrix.Cov khoom no pab cov pob txha mos tau dej thiab cov khoom noj, yog li ua kom cov pob txha mos moist thiab elastic, thiab pab tswj kev ua haujlwm ntawm cov pob qij txha.
Qhov thib ob, cov nyhuv physiological ntawm chondroitin sulfate yog qhov tseem ceeb tshwj xeeb rau cov pob txha mos.Nws tuaj yeem khi cov dej molecules, nqus dej molecules rau hauv cov molecules proteoglycan, ua kom cov pob txha mos thiab ua kom cov kua dej synovial hauv cov kab noj hniav sib koom ua ke, lubricating thiab txhawb kev sib koom tes.Nyob rau hauv txoj kev no, kev sib koom ua ke tuaj yeem txo qhov kev sib txhuam thiab kev cuam tshuam thaum txav mus los, kom cov pob qij txha txav tau yooj yim dua.
Thaum kawg, chondroitin sulfate kuj ua haujlwm hauv pob txha pob txha engineering.Cov kws tshawb fawb tau npaj cov hydrogels sib xyaw ua ke raws li chondroitin sulfate, uas nws tus kheej khi inorganic ions thiab txhawb cov pob txha biomineralization, yog li txhim kho cov pob txha rov tsim dua tshiab.Qhov no muaj cov ntawv thov tseem ceeb rau kev kho mob orthopedic phais xws li kho pob txha thiab pob txha grafting.
1. Txhawb kev noj qab haus huv ntawm kev sib koom tes: Chondroitin sulfate yog ib qho ntawm cov khoom tseem ceeb ntawm cov pob txha mos, uas tuaj yeem pab cov pob txha pob txha kom tswj tau nws cov elasticity thiab dej, thiab yog li tswj cov kev ua haujlwm ntawm kev sib koom tes.Los ntawm kev ntxiv nrog chondroitin sulfate, nws tuaj yeem txhawb kev kho thiab rov tsim dua tshiab ntawm cov pob txha mos, yog li qeeb cov txheej txheem ntawm kev sib koom ua ke.
2. Txo cov mob pob qij txha: chondroitin sulfate tuaj yeem txo cov lus teb inflammatory hauv kev sib koom ua ke, txo cov stimulation ntawm cov leeg synovium, thiab tom qab ntawd txo qhov mob pob qij txha.Qhov no muaj txiaj ntsig zoo rau cov neeg mob uas muaj kab mob sib koom ua ke xws li mob caj dab.
3. Txhim kho kev sib koom ua ke: Chondroitin sulfate txhim kho kev txav mus los thiab yooj yim ntawm kev sib koom ua ke los ntawm kev sib koom ua ke lubrication thiab txo kev sib txhuam ntawm kev sib koom tes.Qhov no ua rau kev sib koom ua ke zoo dua thaum lub sijhawm txav mus los, txo qhov tsis yooj yim los ntawm kev sib koom ua ke nruj lossis kev txav txav tsawg.
4. Tiv thaiv pob txha pob txha: Chondroitin sulfate tuaj yeem cuam tshuam cov pob txha mos ntawm pob txha mos, thiab txhawb kev sib txuas thiab tso tawm ntawm chondrocytes, thiaj li ua lub luag haujlwm tiv thaiv pob txha pob txha.Qhov no yuav pab kom ncua cov txheej txheem ntawm kev sib koom ua ke kev laus thiab degeneration.
1. Kho qhov txhab thiab kho daim tawv nqaij: Chondroitin sulfate ua lub luag haujlwm tseem ceeb hauv kev kho qhov txhab.Nws tuaj yeem txhawb kev rov tsim dua tshiab thiab kho cov ntaub so ntswg, txhim kho elasticity thiab nruj ntawm daim tawv nqaij, thiab pab txo qhov caws pliav.Yog li ntawd, chondroitin sulfate muaj peev xwm siv tau rau hauv cov txheej txheem phais, kho kub hnyiab thiab kho daim tawv nqaij.
2. Kev lag luam tshuaj pleev ib ce: Vim nws cov khoom zoo moisturizing thiab tiv thaiv kev laus, chondroitin sulfate kuj tau siv dav hauv kev lag luam tshuaj pleev ib ce.Nws tuaj yeem ntxiv rau cov khoom tu tawv nqaij ua cov khoom siv moisturizing, pab tswj cov tawv nqaij noo noo sib npaug thiab txhim kho daim tawv nqaij elasticity thiab gloss.Tsis tas li ntawd, chondroitin sulfate tseem tuaj yeem cuam tshuam kev tsim cov dawb radicals, ua kom cov tawv nqaij laus zuj zus, thiab ua rau cov tawv nqaij hluas thiab noj qab nyob zoo.
3. Tissue engineering thiab regenerative tshuaj: Nyob rau hauv lub teb ntawm cov ntaub so ntswg engineering thiab regenerative tshuaj, chondroitin sulfate yog siv los ua ib feem ntawm kev tsim kho ntawm biomimetic stent cov ntaub ntawv.Nws tuaj yeem ua ke nrog lwm cov khoom siv biomaterials los tsim cov Scaffolds nrog cov qauv tshwj xeeb thiab kev ua haujlwm rau kev kho lossis hloov cov ntaub so ntswg thiab cov kabmob uas puas lawm.Lub biocompatibility thiab bioactivity ntawm chondroitin sulfate ua rau nws yog ib tug neeg sib tw tseem ceeb nyob rau hauv lub teb ntawm cov ntaub so ntswg engineering.
4. Cov nyhuv Antitumor: Hauv xyoo tas los no, kev tshawb fawb tau pom tias chondroitin sulfate kuj muaj peev xwm tiv thaiv qog.Nws tuaj yeem inhibit qog pib thiab kev loj hlob los ntawm kev tswj cov kev loj hlob, kev sib txawv thiab cov txheej txheem apoptotic ntawm cov qog hlwb.Txawm hais tias qhov kev tshawb fawb cuam tshuam tseem nyob rau theem pib, kev cia siab rau daim ntawv thov ntawm chondroitin sulfate hauv thaj tsam ntawm kev tiv thaiv qog.
Chondroitin sulfate thiab glucosamine sulfate tsis yog tib hom.Muaj qee qhov sib txawv ntawm lawv qhov sib xyaw, kev siv thiab kev ua haujlwm.
Chondroitin sulfate yog glycosaminoglycan nrog ntau yam kev ua haujlwm lom neeg, nrog rau kev tswj cov lipid thiab tiv thaiv kev mob.Nws yog dav siv nyob rau hauv kev kho mob ntawm osteoarthritis thiab muaj peev xwm txo inflammatory mediators thiab apoptotic txheej txheem, thaum ib txhij txo cov zus tau tej cov inflammatory cytokines, iNOS thiab MMPs.Ntxiv mus, chondroitin sulfate kuj ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab kho cov pob txha pob txha, pab pob txha mos tiv thaiv kev ntxhov siab nyob rau hauv ntau yam kev thauj khoom los ntawm kev ua kom cov ntaub so ntswg tiv taus thiab elastic.
Thiab glucosamine sulfate yog lwm qhov tseem ceeb, uas feem ntau yog siv los tiv thaiv thiab kho ntau yam ntawm osteoarthritis, xws li lub hauv caug pob qij txha thiab pob qij txha.Nws ua rau cov pob txha mos, los ntawm kev txhawb nqa chondrocytes los tsim cov proteoglycans nrog cov qauv polysome, txhim kho lub peev xwm ntawm chondrocytes, inhibit kev puas tsuaj pob txha enzymes xws li collagenase thiab phospholipase A2, thiab tuaj yeem tiv thaiv kev tsim cov superoxidized dawb radicals hauv cov hlwb puas, yog li ncua sijhawm. cov txheej txheem pathological ntawm osteoarthritis thiab kev loj hlob ntawm tus kab mob, txhim kho kev sib koom ua ke, txo qhov mob.
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